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| Lucarini,R.; Tozatti,M.G.; Silva,M.L.A.; Gimenez,V.M.M.; Pauletti,P.M.; Groppo,M.; Turatti,I.C.C.; Cunha,W.R.; Martins,C.H.G.. |
| This paper reports on the in vitro antibacterial and in vivo anti-inflammatory properties of a hydroethanolic extract of the aerial parts of Gochnatia pulchra (HEGP). It also describes the antibacterial activity of HEGP fractions and of the isolated compounds genkwanin, scutellarin, apigenin, and 3,5-O-dicaffeoylquinic acid, as evaluated by a broth microdilution method. While HEGP and its fractions did not provide promising results, the isolated compounds exhibited pronounced antibacterial activity. The most sensitive microorganism was Streptococcus pyogenes, with minimum inhibitory concentration (MIC) values of 100, 50 and 25 µg/mL for genkwanin and the flavonoids apigenin and scutellarin, respectively. Genkwanin produced an MIC value of 25 µg/mL against... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gochnatia pulchra; Anti-inflammatory activity; Antibacterial activity; Medicinal plants; Proinflammatory cytokines. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000900822 |
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